Voriconazole-Induced Photosensitivity in Children
نویسندگان
چکیده
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منابع مشابه
Voriconazole therapy in children with cystic fibrosis.
BACKGROUND There is increasing evidence for the efficacy of the antifungal voriconazole, particularly in immunosuppression. We describe our experience of using voriconazole in children with CF. METHODS We performed a retrospective case note review of children with CF treated with voriconazole in a single centre over an 18 month period. RESULTS A total of 21 children aged 5 to 16 years (medi...
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Voriconazole is a treatment for severe fungal infections. Prolonged voriconazole therapy may induce skin reactions, with 1% of severe photosensitivity accidents. Recently the imputability of voriconazole in skin carcinogenesis has been suggested. This report concerns a 55-year-old man suffering from pulmonary aspergillosis who presented a phototoxic reaction a few months after introduction of v...
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BACKGROUND Prospective evaluation of the antifungal drug, voriconazole, is needed to determine whether drug toxicity correlates with CYP2C19 genotype or serum concentrations of voriconazole or its metabolites. METHODS We conducted a prospective study of 95 patients to determine voriconazole toxicity and its relationship to genotype and serum levels of voriconazole and its two metabolites. Eff...
متن کاملChronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole.
BACKGROUND Voriconazole is a broad-spectrum antifungal agent associated with photosensitivity and accelerated photoaging. A possible link with aggressive squamous cell carcinoma (SCC) has also been reported. OBJECTIVE We sought to determine the incidence and frequency of cutaneous SCC among patients undergoing long-term treatment with voriconazole who also manifest features of chronic phototo...
متن کاملSevere photosensitivity causing multifocal squamous cell carcinomas secondary to prolonged voriconazole therapy.
A 32-year-old woman was treated with long-term voriconazole therapy for recurrent aspergillosis associated with chronic granulomatous disease. A short time after commencement of voriconazole therapy, a severe photosensitivity reaction developed. Continued voriconazole exposure led to the development of multifocal facial squamous cell carcinomas. The photosensitivity reaction resolved after the ...
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2014